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KMID : 0878220050170010130
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Journal of Sasang Constitutional Medicine
2005 Volume.17 No. 1 p.130 ~ p.141
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The Effects of Chungpyesagan-tang on the Recovery of Liver Function in Rat Injured by
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Kim Jeong-Yeol
Shin Mee-Ran
Hep Woon-Young
Kim Dal-Rae
Jeon Jong-Weon
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Abstract
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1. Objectives
The present study was carried out to investigate the effects of Chungpyesagan-tang on the Liver Damage in Rats.
2. Methods
Sprague-Dawley rats were devided into 5 experimental groups : Normal, extract of injection group after Normal Saline feed), extract of injection group after Chungpyesagantang feed), Saline feed group after injection), extract of Chungpyesagantang feed group after injection). Biochemical assays for serum enzyme activities such as AST, ALT, ALP, BUN, Creatinine, Uric Acid, Total Protein, Albumin, Total Cholesterol, Triglyceride, Glucose, and mRNA Revelation of Cytochrome p450 and activities such as LPO(Lipid Peroxidation), GSH(Glutathione), GST(Glutathione-S- Transferase), Glutathione Reductase, Glutathione Peroxidase, SOD(Superoxide Dismutase), Catalase, Hydroxyproline, and were performed.
3. Results
1) showed significantly lower relation of Cytochrome p450 than .
2) As to LPO Hydroxyproline, showed significantly lower activity than .
3) As to GSH GST Glutathione Peroxidase Catalase, showed higher activity than , showed significantly higher activity than .
4) As to Glutathione Reductase SOD, showed significantly higher activity than .
5) As to , showed signficantly lower activity than .
4. Conclusions
Chungpyesagantang has the recovering effects on the Liver Damage.
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KEYWORD
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Chungpyesagan-tang, Liver Damage
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